School of Health Sciences

Risk of autism spectrum disorder and association of its symptoms with psychiatric and substance use disorders in non-clinical student sample in Kenya: cross-sectional study

2025-07-09T07:25:55Z

Risk of autism spectrum disorder and association of its symptoms with psychiatric and substance use disorders in non-clinical student sample in Kenya: cross-sectional study Mutiso, Victoria N.; Ndetei, David M.; Muia, Esther N.; Masake, Monicah; Alietsi, Rita K.; Onsinyo, Lydia; Musyimi, Christine; Mamah, Daniel Background The prevalence and patterns of autism spectrum disorder (ASD) symptoms/traits and the associations of ASD with psychiatric and substance use disorders has not been documented in nonclinical students in Sub-Saharan Africa, and Kenya in particular. Aims To document the risk level of ASD and its traits in a Kenyan student population (high school, college and university) using the Autism-Spectrum Quotient (AQ); and to determine the associations between ASD and other psychiatric and substance use disorders. Method This was a cross-sectional study among students (n = 9626). We used instruments with sufficient psychometric properties and good discriminative validity to collect data. A cut-off score of ≥32 on the AQ was used to identify those at high risk of ASD. We conducted the following statistical tests: (a) basic descriptive statistics; (b) chi-squared tests and Fisher’s exact tests to analyse associations between categorical variables and ASD; (c) independent t-tests to examine two-group comparisons with ASD; (d) one-way analysis of variance to make comparisons between categorical variables with three or more groups and ASD; (e) statistically significant (P < 0.05) variables fitted into an ordinal logistic regression model to identify determinants of ASD; (f) Pearson’s correlation and reliability analysis. Results Of the total sample, 54 (0.56%) were at high risk of ASD. Sociodemographic differences were found in the mean scores for the various traits, and statistically significant (P < 0.05) associations we found between ASD and various psychiatric and substance use disorders. Conclusions Risk of ASD, gender characteristics and associations with psychiatric and substance use disorders are similar in this Kenyan sample to those found in Western settings in non-clinical populations.

Caregiver factors influencing nutritional status of preschool children in Mwingi West, Kitui County Kenya.

2025-07-09T07:24:08Z

Caregiver factors influencing nutritional status of preschool children in Mwingi West, Kitui County Kenya. Mbijiwe, Jane; Ndung’u, Zipporah; Kinyuru, John Children are at an increased risk of malnutrition, with many undernourished children being highly susceptible to preventable premature death and morbidity. Insufficient dietary intake, infections, food insecurity, and inadequate care are the main causes of child malnutrition. These factors are sequentially influenced by caregivers’ characteristics. Despite this, the effect of a caregiver’s characteristics on a child's nutrition status has not been exhaustively studied in rural areas of Kenya. It is important to continuously examine the trends in the prevalence of malnutrition for effective interventions. Regular updates on the prevalence of malnutrition are crucial for appropriate interventions. In this study, the nutritional status of children was evaluated alongside their association with caregivers’ characteristics. The study was based in Migwani ward, Mwingi West Sub-County in Kitui County. The study was conducted between October and December 2020 and involved 106 caregivers with their 106 children aged 36–42 months. The characteristics of the caregivers were determined by the use of a pretested study questionnaire. To evaluate the nutritional status of children, the height and weight measures, age, and sex of the child were taken and transferred into the WHO Anthro software, and zscores were derived. The Statistical Package for the Social Sciences (SPSS) was used to carry out additional data analysis. Children's nutritional status and caregivers’ characteristics were bivariate tested to determine the association. In the present study, the prevalence of stunting was 33.0%, wasting was 15.1%, and underweight was 20.8%. In this study, the caregivers that had lower income had more children that were underweight (χ2 = 9.2 p = 0.02), stunted (χ2 = 10.4 p = 0.015) and wasted (χ2 = 16.9, p<0.001) compared to those with higher incomes. More so, the caregivers that were younger had more children that were wasted (χ2 = 20.04, p<0.001), stunted (χ2 = 9.65, p = 0.032) and underweight (χ2 = 8.26, p = 0.041). Households that were headed by women had more children that were stunted (p = 0.022), wasted (p = 0.041) and underweight (p = 0.003). Similarly, respondents with lower education levels had more children that were stunted (χ2 = 14.02, p = 0.003), wasted (χ2 = 4.85, p = 0.037) and underweight (χ2 = 4.76, p = 0.045). In this study, the caregiver’s occupation was significantly associated with children's stunting (χ2 = 12.23, p = 0.007) and underweight levels (χ2 = 6.12, p = 0.034). The caregiver’s occupation had no influence on the children's wasting levels. The present study found that the marital status of a caregiver did not influence a child's nutritional status. These study results affirm that nutritional problems of stunting, wasting, and underweight among preschool children in Kitui County require public health actions. That caregivers’ characteristics play a role in the nutritional status of preschool children in Kitui County. Based on these study findings, priority should be given to children's nutrition programs that incorporate the dynamics of caregivers' characteristics. By doing this, such programs will be more effective.

Students stress patterns in a Kenyan socio-cultural and economic context: toward a public health intervention

2025-07-09T07:24:44Z

Students stress patterns in a Kenyan socio-cultural and economic context: toward a public health intervention Mutiso, Victoria N.; Ndetei, David M.; Muia, Esther N.; Musyimi, Christine; Masake, Monicah; Osborn, Tom L.; Andre, Sourander; Weisz, John R.; Mamah, Daniel This study aimed at determining the prevalence of stress, different types of stress, their severity and their determinants in Kenyan university, college and high school students. The following tools were administered to 9741 students: (1) Researcher-designed socio-demographic tool, (2) Psychiatric Diagnostic Screening Questionnaire (PDSQ) for psychiatric disorders, (3) WERC Stress Screen for stress, (4) Washington Early Recognition Center Affectivity and Psychosis (WERCAP) screen for psychosis and affectivity, (5) Wealth Index Questionnaire for economic indicators. Descriptive analysis for the prevalence of different types of stress and inferential analysis for stress and independent variables were done. Significant variables (p < 0.05) were fitted into generalized linear model to determine independent predictors. The mean age of the respondents was 21.4 years (range 16–43). Money issues were the commonest stressors while alcohol and drug use were the least. The independent predictors of stress were females, college students and use of gas stove. In conclusion, up to 30% of the students suffer from mild to severe stress. The students experience a wide range of stressors. The most important stressors include money and finances, family related problems and concerns about their future. Our findings suggest a public health approach to create stress awareness in students.

Enrichment of Fermented Sorghum Flour with Pumpkin Pulp and Seed for Production of a Vitamin A and Iron Enhanced Supplementary Food

2025-07-09T07:18:26Z

Enrichment of Fermented Sorghum Flour with Pumpkin Pulp and Seed for Production of a Vitamin A and Iron Enhanced Supplementary Food Mbijiwe, Jane; Ndung’u, Zipporah; Kinyuru, John Vitamin A and iron deficiencies are prevalent in preschool children being a public health concern. The study aimed at developing a flour blend formulation made of sorghum, pumpkin pulp and seeds and examining its contribution to the daily nutrient requirement for iron and vitamin A among preschool children. Three flour blends were formulated using a mixture of fermented sorghum flour, pumpkin seed flour and pumpkin pulp flour with the following ratios 80:10:10 (FP1), 70:15:15 (FP2) and 60:20:20 (FP3), respectively whereas control was made of 100% fermented sorghum flour. The flour blends and the control were analyzed for moisture content, protein, crude fiber, crude fat, ash, carbohydrate, beta-carotene and iron content. Further, sensory tests were conducted using a nine-hedonic scale to evaluate consumers acceptability of porridge made of the flour samples. Microbial analysis was conducted to establish the safety of developed flours. The results show that as the proportion of pumpkin pulp and pumpkin seed flours increased the protein content, ash, vitamin A and iron content significantly (P<0.05) increased. The flour blend FP3 recorded the highest amount of protein (22.87%), vitamin A (875.00 µg RAE/100g) and iron (27.51 mg/100g). The FP2 flour blend was the most preferred with sensory score of 7.91 and had ability to meet >70% of daily protein, iron and vitamin A requirements of preschool children thus most suitable for a feeding trial. The findings of this study demonstrate that pumpkin pulp and pumpkin seed can be used to enhance the nutritive value of sorghum and as such meet the protein, iron and vitamin A requirements of preschool children aiding in the eradication of nutritional deficiencies.