| dc.description.abstract | Molecular recognition based on imprinted polymers results from the polymerization of
functional monomers and cross-linkers in the presence of a target analyte (i.e. template),
with subsequent removal of the template to create synthetic binding sites. However, complete
removal of the template is difficult to achieve, thereby leading to template leaching,
which adversely affects real-world analytical applications. To overcome this challenge, the
present study utilizes porogenic fragment template imprinting techniques to provide an
alternative synthetic strategy to generate molecularly imprinted polymers with molecular
recognition toward polychlorinated biphenyls. Thereafter, thus-generated imprinted polymers
have been applied as stationary phases in molecularly imprinted solid-phase extraction
for preconcentrating six “indicator polychlorinated biphenyls” in both organic and aqueous
media. Recoveries of up to 98.9% (imprinted polymers) versus 73.0% (conventional C18)
in an organic phase, and up to 97.4% (imprinted polymers) versus 89.4% (C18) in an
aqueous phase have been achieved corroborating the utility of this advanced sorbent material.
Finally, porogenic fragment template imprinting strategies have yielded molecularly
imprinted polymers that are useful for the quantitative determination of polychlorinated
biphenyls in environmental matrices, which provides a low-cost strategy for tailoring stationary
phases that avoid template leaching in applications in solid-phase extraction as well
as liquid chromatography. | en_US |
